Daniela Sofía Del Salto

Gaststudentin (Universidad Internacional de Valencia, Spain)

3D PRINTING OF HYDROGEL SCAFFOLDS BASED ON OXIDIZED ALGINATE (ADA-GEL) AND MESOPOROUS BIOACTIVE GLASS NANOPARTICLES LOADED WITH PLANT DERIVED BIOACTIVE COMPOUNDS FOR BONE TISSUE ENGINEERING

 

Supervisors: Ph.D stud. Luiza Mirt, Prof. Aldo R. Boccaccini

3D printing of scaffolds made from biomaterials, such as alginate based hydrogels, which provides a biocompatible and biodegradable matrix [1], and mesoporous bioactive glass nanoparticles (MBGNs), which stimulate bone regeneration due to their bioactivity [2], represents a promising strategy in tissue engineering. This technology offers tailor made solutions for bone tissue regeneration. The aim of this study is to develop hybrid composite scaffolds through 3D printing, using a hydrogel based on oxidized alginate-gelatine (ADA-Gel) and MBGNs functionalized with plant derived active compounds. Due to their antimicrobial and antioxidant properties, some phytotherapeutic compounds promote a favorable environment for osteogenesis, maximizing the regenerative potential of the material [3].

[1]      D. R. Sahoo y T. Biswal, «Alginate and its application to tissue engineering», SN Appl. Sci., vol. 3, n.o 1, p. 30, ene. 2021, doi: 10.1007/s42452-020-04096-w.

[2]      F. Bider et al., «Enhancing alginate dialdehyde-gelatin (ADA-GEL) based hydrogels for biofabrication by addition of phytotherapeutics and mesoporous bioactive glass nanoparticles (MBGNs)», J. Biomater. Appl., p. 8853282241280768, sep. 2024, doi: 10.1177/08853282241280768.

[3]      H. Elkhenany, N. El-Badri, y M. Dhar, «Green propolis extract promotes in vitro proliferation, differentiation, and migration of bone marrow stromal cells», Biomed. Pharmacother. Biomedecine Pharmacother., vol. 115, p. 108861, jul. 2019, doi: 10.1016/j.biopha.2019.108861.