Andrada-Ioana Damian-Buda

Visiting researcher (University Politehnica of Bucharest, Romania)

Drug loaded mesoporous bioactive glass nanoparticles for wound healing applications

 

Supervisor: Prof. Aldo R. Boccaccini

In the past years mesoporous bioactive glass nanoparticles (MBGNs) have gained a lot of popularity as multifunctional platforms not only for bone tissue engineering [1], but also for soft tissue applications [2]. When it comes to wound healing, the presence of different ions in the MBGNs’ structure leads to several therapeutic effects (hemostatic, antibacterial, angiogenesis, etc.), specifically targeting the regeneration process [3]. At the same time, the unique textural properties of the MBGNs could assure a high drug loading efficiency and a controlled release of active compounds over long periods of time [4], [5]. Thus, one of the aims of this study is to develop and characterise MBGNs loaded with phytoterapeutic agents. These particles will be further incorporated in a hydrogel with the purpose of obtaining composite scaffolds with enhanced properties for skin regeneration.

[1] F. Kurtuldu et al., “Cerium and gallium containing mesoporous bioactive glass nanoparticles for bone regeneration: Bioactivity, biocompatibility and antibacterial activity,” Mater. Sci. Eng. C. vol. 124, May 2021, doi: 10.1016/J.MSEC.2021.112050.

[2] K. Zheng et al., “Ag modified mesoporous bioactive glass nanoparticles for enhanced antibacterial activity in 3D infected skin model,” Mater. Sci. Eng. C, vol. 103, Oct. 2019, doi: 10.1016/J.MSEC.2019.109764.

[3] S. Kargozar et al., “Using bioactive glasses in the management of burns,” Front. Bioeng. Biotechnol., vol. 7, 2019, doi: 10.3389/FBIOE.2019.00062/BIBTEX.

[4] F. Bider et al., “Advantages of nanoscale bioactive glass as inorganic filler in alginate hydrogels for drug delivery and biofabrication”, European Journal of Materials, vol. 2, no. 1, pp. 33–53, Dec. 2022, doi: 10.1080/26889277.2022.2039078.

[5] Q. Nawaz et al., “Silibinin releasing mesoporous bioactive glass nanoparticles with potential for breast cancer therapy,” Ceram. Int., vol. 46, no. 18, pp. 29111–29119, Dec. 2020, doi: 10.1016/J.CERAMINT.2020.08.083.