Boyang Xu

Master student

Biocompatible and mechanical robust 3D printed ADA-GEL scaffolds loaded with phytochemicals and naturally derived substances for skin tissue engineering applications

 

Supervisors: Memoona Akhtar, Prof. Aldo R. Boccaccini

ADA-GEL is the combination of alginate di-aldehyde and gelatin, which gains high biocompatibility, adjustable biodegradability and low production cost [1]. Natural products including plant-derived extracts (phytochemicals) and naturally derived substances are important alternative medicines, which are safe and effective [2]. The aim of this study is to design a biocompatible and robust ADA-GEL scaffold for skin tissue engineering which is loaded with natural compounds, in relation with previous recent research in our Institute [3] Related properties will be tested, including biocompatibility, mechanical properties, drug-release kinetic, etc.

[1] Reakasame S, Boccaccini AR. Oxidized Alginate-Based Hydrogels for Tissue Engineering Applications: A Review. Biomacromolecules 2018; 19(1):3–21.

[2] Sivamani, Raja K., et al. Phytochemicals and Naturally Derived Substances for Wound Healing. Advances in Wound Care, 2012, 1: 213–17.

[3] Monavari, M., et al., A 3D-Printed Wound-Healing Material Composed of Alginate Dialdehyde–Gelatin Incorporating Astaxanthin and Borate Bioactive Glass Microparticles, ACS Appl. Mater. Interfaces 2023, in press.