Chenyi Ge

Betreuer: Dr. Qaisar Nawaz, Prof. Aldo R. Boccaccini

In comparison to traditional bioactive glasses, mesoporous bioactive glass nanoparticles (MBGNs) exhibit significant enhancements in pore volume, specific surface area, and its ability to mineralize apatite. [1] Utilizing sol-gel synthesis process MBGNs could be produced at a lower temperature, higher homogeneity and purity and be formed in multiscale porosity over melt-derived products.[2] The integration of nanoparticles into 3D-printed Polycaprolactone (PCL) scaffolds represents a cutting-edge approach in the field of biomaterials and tissue engineering. Polycaprolactone (PCL) is an FDA-approved polymer recognized for its biodegradability. Its ability to undergo low-temperature processing makes it ideal for 3D printing. PCL degrades slowly, yielding non-toxic byproducts. [3] A recent interesting research area is the development of hybrid hydrogel composites by combining printed tough hydrogels as the scaffold and soft hydrogels as the filled substance. [4] Alginate dialdehyde-gelatin (ADA-GEL) shows exceptional cytocompatibility with various cell types and tunable mechanical properties, making it a promising biomaterial candidate for soft tissue applications, such as artificial blood vessels. [5]
This Master thesis focuses on 3D-printed PCL-MBGNs composite scaffold combined with ADA-GEL. Studies on the interfacial bonding between filler and scaffold material, the distribution of the filler within the scaffold, mechanical and biological properties will be investigated.