Selin Yasar

Former visiting student (Yıldız Technical University, Turkey)

Mesoporous Bioactive Glass Nanoparticles and Clove Oil Loaded 3D Printed Scaffolds

 

Supervisors: Irem Unalan, Prof. Aldo R. Boccaccini

Essential oils are natural phytotherapeutic agents used in pharmaceutics, cosmetics, and food industries since ancient times. In particular, Clove oil (CLV) attracts attention because of its anti-bacterial, and anti-inflammatory properties in biomaterials [1]. On the other hand, mesoporous bioactive glass nanoparticles (MBGNs) have been used for soft and hard tissue engineering applications due to their therapeutic effect on angiogenesis and osteogenesis [2]. This Project aims to combine CLV and MBGNs into three-dimensional (3D) scaffolds produced via the extrusion-based 3D-printing method. In this regard, the optimized scaffolds will be investigated in terms of their physical, chemical, and mechanical properties, as well as their anti-oxidant and anti-bacterial activity.

[1]  I. Unalan et al., “Evaluation of Electrospun Poly(ε-Caprolactone)/Gelatin Nanofiber Mats Containing Clove Essential Oil for Antibacterial Wound Dressing“, Pharmaceutics, 2019 doi: 10.3390/pharmaceutics11110570.

[2]    S. Hooshmand et al., “Mesoporous Silica Nanoparticles and Mesoporous Bioactive Glasses for Wound Management: From Skin Regeneration to Cancer Therapy,” Materials, 2021, doi: 10.3390/ma14123337.