Téraube Nicolas

Ehemaliger Gaststudent (University of Limoges, ENSIL-ENSCI Department of Industrial Ceramics, France)

Development and characterization of ion releasing bioactive glass based scaffolds intended for bone repair

 

Supervisors: Dr.-Ing. Qaisar Nawaz, Zhiyan Xu, Prof. Dr.-Ing. habil. Aldo R. Boccaccini

Bioactive glass scaffolds are investigated for bone tissue engineering, as they have great characteristics to stimulate bone regeneration. They are biodegradable, cytocompatible, promote cell adhesion, stimulate osteogenesis and form a strong bond with bone [1]. In this project, we produce scaffolds using 45S5 bioactive glass microparticles by foam replication method [2]. Moreover, these scaffolds will be coated by mesoporous bioactive glass nanoparticles (MBGNPs), synthesized by the micro-emulsion technique based on the Sol-Gel method [3]. In addition, we will incorporate biologically active ions [4] [5] into the MBGNPs, to endow them with biological multifunctionality like antioxidant, angiogenic, antibacterial properties. The characterization of the new materials will involve mechanical properties, surface properties and in vitro bioactivity studies.

[1] J. R. Jones, L. M. Ehrenfried, L. L. Hench, Optimising bioactive glass scaffolds for bone tissue engineering, Biomaterials, 2006, 27.7, 964-973

[2] Q. Z. Chen, I. D. Thompson, A. R. Boccaccini, 45S5 Bioglass®-derived glass–ceramic scaffolds for bone tissue engineering, Biomaterials, 2006, 27.11, 2414-2425

[3] K. Zheng, & A. R. Boccaccini, Sol-gel processing of bioactive glass nanoparticles: A review, Advances in Colloid and Interface Science, 2017, 249, 363-373

[4] F. Kurtuldu, H. Kaňková, A. M. Beltrán, L. Liverani, D. Galusek, A. R. Boccaccini, Anti-inflammatory and antibacterial activities of cerium-containing mesoporous bioactive glass nanoparticles for drug-free biomedical applications, Materials Today Bio, 2021, 12, 100150

[5] V. Vijayan Msc, S. Sreekumar Msc, F. Singh Msc, K. V. Srivatsan Msc , R. Lakra PhD , K. P. Sai PhD, M. S. Kiran PhD, Nanotized praseodymium oxide collagen 3-D pro-vasculogenic biomatrix for soft tissue engineering, Nanomedicine: Nanotechnology, Biology and Medicine, 2021 33, 102364