Svenja Heise - Lehrstuhl Biomaterialien

Svenja Heise

Cauerstraße 6
Deutschland

Doktorandin

Development of advanced biodegradable and bioactive coatings for Mg alloys

Mg and Mg-alloys are promising temporary implants due to their outstanding combination of good mechanical properties, biocompatibility and degradability in the human body. The benefit of such a materials is huge, as no second operation for the removal of the implant is needed. The main problem for the application of Mg and Mg-alloys in the biomedical field is, however, the excessive corrosion these materials exhibit, combined with an increase of pH and the formation of hydrogen. Application of coatings is a convenient approach to tackle this problem [1]. The objective of this research is the development of a bioadaptive coating system on Mg-alloys. The top layer of the coating system will be a polymer-inorganic phase composite. The interaction of the layers with the electrolyte, proteins and cells will be investigated and the effect of the coatings on the corrosion process, including the adhesion to the substrates, will be analysed. The project is a DFG funded effort in collaboration with Prof. S. Virtanen (Institute of Surface Science and Corrosion), Dr. H. Hornberger (Institute of Biomaterials and Institute of Surface Science and Corrosion) and Prof. F. Witte (Charite, Berlin)

2020

Sotniczuk A., Heise S., Topolski K., Garbacz H., Boccaccini AR.:
Chitosan/bioactive glass coatings as a protective layer against corrosion of nanocrystalline titanium under simulated inflammation
In: Materials Letters 264 (2020), Art.Nr.: 127284
ISSN: 0167-577X
DOI: 10.1016/j.matlet.2019.127284

2019

Heise S., Forster C., Heer S., Qi H., Zhou J., Virtanen S., Lu T., Boccaccini AR.:
Electrophoretic deposition of gelatine nanoparticle/chitosan coatings
In: Electrochimica Acta 307 (2019), S. 318-325
ISSN: 0013-4686
DOI: 10.1016/j.electacta.2019.03.145
Höhlinger M., Christa D., Zimmermann V., Heise S., Boccaccini AR., Virtanen S.:
Influence of proteins on the corrosion behavior of a chitosan-bioactive glass coated magnesium alloy
In: Materials Science and Engineering C 100 (2019), S. 706-714
ISSN: 0928-4931
DOI: 10.1016/j.msec.2019.02.034
Qi H., Heise S., Zhou J., Schuhladen K., Yang Y., Cui N., Dong R., Virtanen S., Chen Q., Boccaccini AR., Lu T.:
Electrophoretic Deposition of Bioadaptive Drug Delivery Coatings on Magnesium Alloy for Bone Repair
In: ACS Applied Materials and Interfaces 11 (2019), S. 8625-8634
ISSN: 1944-8244
DOI: 10.1021/acsami.9b01227

2018

Dominguez-Trujillo C., Ternero F., Rodriguez-Ortiz JA., Heise S., Boccaccini AR., Lebrato J., Torres Y.:
Bioactive coatings on porous titanium for biomedical applications
In: Surface & Coatings Technology 349 (2018), S. 584-592
ISSN: 0257-8972
DOI: 10.1016/j.surfcoat.2018.06.037
Dominguez-Trujillo C., Ternero F., Rodriguez-Ortiz JA., Heise S., Boccaccini AR., Lebrato J., Torres Y.:
Bioactive coatings on porous titanium for biomedical applications
In: Surface & Coatings Technology 349 (2018), S. 584-592
ISSN: 0257-8972
DOI: 10.1016/j.surfcoat.2018.06.037
Heise S.:
Development of advanced chitosan-based biodegradable coatings for Mg alloys with potential applications in orthopedic implants (Dissertation, 2018)
Heise S., Ramos Rivera L., Boccaccini AR.:
Bioactive Glass Containing Coatings by Electrophoretic Deposition: Development and Applications
In: Gurbinder Kaur (Hrsg.): Biomedical, Therapeutic and Clinical Applications of Bioactive Glasses, Woodhead Publishing, 2018
ISBN: 9780081021965
DOI: 10.1016/b978-0-08-102196-5.00001-x
Heise S., Virtanen S., Boccaccini AR.:
Taguchi Design of Experiments approach to determine process parameter for the electrophoretic deposition of chitosan/bioactive glass on Mg alloy substrates
In: ECS Transactions 82 (2018), S. 81-87
ISSN: 1938-5862
DOI: 10.1149/08201.0081ecst
Heise S., Wirth T., Höhlinger M., Torres Hernández Y., Rodriquez Ortiz JA., Wagener V., Virtanen S., Boccaccini AR.:
Electrophoretic deposition of chitosan/bioactive glass/silica coatings on stainless steel and WE43 Mg alloy substrates
In: Surface & Coatings Technology 344 (2018), S. 553-563
ISSN: 0257-8972
DOI: 10.1016/j.surfcoat.2018.03.050
Yang Y., Zhou J., Detsch R., Taccardi N., Heise S., Virtanen S., Boccaccini AR.:
Biodegradable nanostructures: Degradation process and biocompatibility of iron oxide nanostructured arrays
In: Materials Science and Engineering C 85 (2018), S. 203-213
ISSN: 0928-4931
DOI: 10.1016/j.msec.2017.12.021

2017

Heise S., Höhlinger M., Torres Hernández Y., Pavón Palacio JJ., Rodriquez Ortiz JA., Wagener V., Virtanen S., Boccaccini AR.:
Electrophoretic deposition and characterization of chitosan/bioactive glass composite coatings on Mg alloy substrates
In: Electrochimica Acta 232 (2017), S. 456-464
ISSN: 0013-4686
DOI: 10.1016/j.electacta.2017.02.081
Höhlinger M., Heise S., Wagener V., Boccaccini AR., Virtanen S.:
Developing surface pre-treatments for electrophoretic deposition of biofunctional chitosan-bioactive glass coatings on a WE43 magnesium alloy
In: Applied Surface Science 405 (2017), S. 441-448
ISSN: 0169-4332
DOI: 10.1016/j.apsusc.2017.02.049

2016

Heise S., Virtanen S., Boccaccini AR.:
Tackling Mg alloy corrosion by natural polymer coatings - A review
In: Journal of Biomedical Materials Research Part A 104 (2016), S. 2628-2641
ISSN: 1549-3296
DOI: 10.1002/jbm.a.35776