Irem Ünalan
Irem Ünalan
ehemalige Doktorandin
Bioactive Scaffolds Containing Essential Oils for Tissue Engineering Applications
Betreuer: Prof. Dr.-Ing. habil. Aldo R. Boccaccini
Herbal medicines based on plant extracts such as rosemary, peppermint, lavender, lemongrass, cinnamon, thyme and grape seed have been used to accelerate the wound healing process since ancient times due to their anti-inflammatory, antimicrobial, antibacterial, antiviral, and antifungal properties [1]. This research project aims to investigate new strategies for design, development and characterization of essential oil-based biodegradable polymeric scaffolds for wound healing process. The combination of essential oil with polymers to improve antibacterial potential of the scaffolds will be examined. The obtained materials will be characterized in terms of surface and mechanical properties, antibacterial activity, and biological compatibility in order to assess their suitability for enhancing the wound healing process.
[1]Bakkali, F., et al., Biological effects of essential oils–a review. Food and chemical toxicology, 2008. 46(2): p. 446-475.
2024
Combining Mesoporous Bioactive Glass Nanoparticles (MBGNs) with Essential Oils to Tackle Bacterial Infection and Oxidative Stress for Bone Regeneration Applications
In: ACS Biomaterials Science and Engineering (2024)
ISSN: 2373-9878
DOI: 10.1021/acsbiomaterials.4c00218 , , :
Bioengineered 3D ovarian model for long-term multiple development of preantral follicle: bridging the gap for poly(ε-caprolactone) (PCL)-based scaffold reproductive applications
In: Reproductive Biology and Endocrinology 22 (2024), Art.Nr.: 95
ISSN: 1477-7827
DOI: 10.1186/s12958-024-01266-y , , , , , , , , , , :
Impact of morphological features and chemical composition of tendon biomimetic scaffolds on immune recognition via Toll-like receptors
In: Biomaterials Science (2024)
ISSN: 2047-4830
DOI: 10.1039/d4bm00147h , , , , , , , , , , :
Hydroxycarbonate apatite formation, cytotoxicity, and antibacterial properties of rubidium-doped mesoporous bioactive glass nanoparticles
In: Journal of Porous Materials (2024)
ISSN: 1380-2224
DOI: 10.1007/s10934-023-01546-9 , , , :
Cotton wool-like ion-doped bioactive glass nanofibers: investigation of Zn and Cu combined effect
In: Biomedical Materials (Bristol) 19 (2024), Art.Nr.: 065001
ISSN: 1748-605X
DOI: 10.1088/1748-605X/ad7084 , , , , , , :
Phytotherapeutic Hierarchical PCL-Based Scaffolds as a Multifunctional Wound Dressing: Combining 3D Printing and Electrospinning
In: Macromolecular Bioscience (2024)
ISSN: 1616-5187
DOI: 10.1002/mabi.202400253 , , , :
2023
Melaleuca armillaris Essential Oil as an Antibacterial Agent: The Use of Mesoporous Bioactive Glass Nanoparticles as Drug Carrier
In: Nanomaterials 13 (2023), Art.Nr.: 34
ISSN: 2079-4991
DOI: 10.3390/nano13010034 , , , , , :
Multifunctional Chitosan Scaffold Platforms Loaded with Natural Polyphenolic Extracts for Wound Dressing Applications
In: Biomacromolecules 24 (2023), S. 5183-5193
ISSN: 1525-7797
DOI: 10.1021/acs.biomac.3c00727 , , , , :
Quaternary and pentanar mesoporous bioactive glass nanoparticles as novel nanocarriers for gallic acid: Characterisation, drug release and antibacterial activity
In: Ceramics International (2023)
ISSN: 0272-8842
DOI: 10.1016/j.ceramint.2023.06.250 , , , , :
Development of Super-Paramagnetic Iron Oxide Nanoparticle-Coated Melt Electrowritten Scaffolds for Biomedical Applications
In: Macromolecular Bioscience (2023)
ISSN: 1616-5187
DOI: 10.1002/mabi.202300397 , , , , :
3D-Printed Multifunctional Hydrogels with Phytotherapeutic Properties: Development of Essential Oil-Incorporated ALG-XAN Hydrogels for Wound Healing Applications
In: ACS Biomaterials Science and Engineering (2023)
ISSN: 2373-9878
DOI: 10.1021/acsbiomaterials.3c00406 , , , :
2022
Fabrication of Biocompatible Electrospun Poly(epsilon-caprolactone)/Gelatin Nanofibers Loaded with Pinus radiata Bark Extracts for Wound Healing Applications
In: Polymers 14 (2022)
ISSN: 2073-4360
DOI: 10.3390/polym14122331 , , , :
Effect of Zn and Ga doping on bioactivity, degradation, and antibacterial properties of borate 1393-B3 bioactive glass
In: Ceramics International (2022)
ISSN: 0272-8842
DOI: 10.1016/j.ceramint.2022.02.192 , , , , , , , , , :
Quaternary bioactive glass-derived powders presenting submicrometric particles and antimicrobial activity
In: Ceramics International (2022)
ISSN: 0272-8842
DOI: 10.1016/j.ceramint.2022.06.266 , , , , , :
In vitro cytocompatibility and antibacterial studies on biodegradable Zn alloys supplemented by a critical assessment of direct contact cytotoxicity assay
In: Journal of Biomedical Materials Research Part B: Applied Biomaterials (2022)
ISSN: 1552-4973
DOI: 10.1002/jbm.b.35147 , , , , , , , , , , , , :
2021
Fabrication and characterization of cinnamaldehyde-loaded mesoporous bioactive glass nanoparticles/phbv-based microspheres for preventing bacterial infection and promoting bone tissue regeneration
In: Polymers 13 (2021), Art.Nr.: 1794
ISSN: 2073-4360
DOI: 10.3390/polym13111794 , , , , , :
Cellular Response to Sol-Gel Hybrid Materials Releasing Boron and Calcium Ions
In: ACS Biomaterials Science and Engineering (2021)
ISSN: 2373-9878
DOI: 10.1021/acsbiomaterials.0c01546 , , , , , , :
Essential oils in biomedical applications: Recent progress and future opportunities
In: Current Opinion in Biomedical Engineering 17 (2021), Art.Nr.: 100261
ISSN: 2468-4511
DOI: 10.1016/j.cobme.2021.100261 , :
Antibacterial and antioxidant activity of cinnamon essential oil-laden 45S5 bioactive glass/soy protein composite scaffolds for the treatment of bone infections and oxidative stress
In: Materials Science and Engineering C 128 (2021), Art.Nr.: 112320
ISSN: 0928-4931
DOI: 10.1016/j.msec.2021.112320 , , , , :
2019
Bioactive glass (45S5)-based 3D scaffolds coated with magnesium and zinc-loaded hydroxyapatite nanoparticles for tissue engineering applications
In: Colloids and Surfaces B: Biointerfaces 182 (2019), Art.Nr.: 110346
ISSN: 0927-7765
DOI: 10.1016/j.colsurfb.2019.110346 , , , , , , , :
Bioactıve Glass-Polymer Nanocomposites for Bone Tıssue Regeneration Applicatıons: A Revıew
In: Advanced Engineering Materials (2019), Art.Nr.: 1900287
ISSN: 1438-1656
DOI: 10.1002/adem.201900287 , , , , :
Evaluation of electrospun poly(ε-caprolactone)/gelatin nanofiber mats containing clove essential oil for antibacterial wound dressing
In: Pharmaceutics 11 (2019), Art.Nr.: 570
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics11110570 , , , , , , :
Physical and Antibacterial Properties of Peppermint Essential Oil Loaded Poly (epsilon-caprolactone) (PCL) Electrospun Fiber Mats for Wound Healing
In: Frontiers in Bioengineering and Biotechnology 7 (2019), Art.Nr.: 346
ISSN: 2296-4185
DOI: 10.3389/fbioe.2019.00346 , , , , , :