Qaisar Nawaz
Qaisar Nawaz
Ehemaliger Doktorand
Mesoporous bioactive glasses with metallic ion and biomolecule releasing capability
Betreuer: Prof. Dr.-Ing. habil. Aldo R. Boccaccini
The aim of this research is to develop multifunctional mesoporous bioactive glass vehicles as therapeutic carriers of biologically active ions and biomolecules for bone regeneration applications. Such highly ordered mesoporous bioactive glass particles will be made by a template guided approach. 3D printing and form replica method will be used to fabricate 3D scaffolds of different pore architecture which will be functionalised by mesoporous particles following previous approaches developed at the Erlangen Institute of Biomaterials [1]. The novel materials will be fully characterized in order to assess its suitability for bone regeneration applications, including microstructural characterisation, testing of mechanical properties, assessment of drug release kinetics, and determination of cytocompatibility.
[1] Boccardi, E., Philippart, A., Bortuzzo, J., Beltran, A., Novarja, G., Vitale Brovarone, C., Spiecker, E., Boccaccini, A. R., Uniform surface modification of 3D Bioglass®-based scaffolds with mesoporous silica particles (MCM-41) for enhancing drug delivery capability, Front. Bioeng. Biotechnol. 3 (2015):177. doi: 10.3389/fbioe.2015.00177.
2024
Effects of silicon nitride (Si3N4) incorporation on physicochemical, bioactivity and antibacterial properties of 45S5 bioactive glass
In: Ceramics International 50 (2024), S. 50200-50212
ISSN: 0272-8842
DOI: 10.1016/j.ceramint.2024.09.367 , , , , , :
Polymer-derived Biosilicate-C composite foams: In-vitro bioactivity, biocompatibility and antibacterial activity
In: Journal of the European Ceramic Society (2024)
ISSN: 0955-2219
DOI: 10.1016/j.jeurceramsoc.2024.03.006 , , , , , , :
Biomolecule and Ion Releasing Mesoporous Nanoparticles: Nonconvergent Osteogenic and Osteo-immunogenic Performance
In: ACS Applied Materials and Interfaces (2024)
ISSN: 1944-8244
DOI: 10.1021/acsami.4c17540 , , , , , :
Osteogenic and angiogenic potential of molybdenum-containing mesoporous bioactive glass nanoparticles: An ionic approach to bone tissue engineering
In: Journal of Trace Elements in Medicine and Biology 86 (2024), Art.Nr.: 127518
ISSN: 0946-672X
DOI: 10.1016/j.jtemb.2024.127518 , , , , , , , :
Processing and cytocompatibility of Cu-doped and undoped fluoride-containing bioactive glasses
In: Open Ceramics 18 (2024), Art.Nr.: 100586
ISSN: 2666-5395
DOI: 10.1016/j.oceram.2024.100586 , , , :
Process- and topography-related cell viability on laser sintered polypropylene
8th China-Europe Symposium on Biomaterials in Regenerative Medicine (Nürnberg, 15. September 2024 - 18. September 2024) , , , , :
New Insights Into Application Relevant Properties of Cu2+-Doped Brushite Cements
In: Journal of Biomedical Materials Research Part B: Applied Biomaterials 112 (2024), Art.Nr.: e35479
ISSN: 1552-4973
DOI: 10.1002/jbm.b.35479 , , , , , , :
Unlocking the potential of iron-containing mesoporous bioactive glasses: Orchestrating osteogenic differentiation in bone marrow mesenchymal stem cells and osteoblasts
In: Colloids and Surfaces A-Physicochemical and Engineering Aspects 694 (2024), Art.Nr.: 134188
ISSN: 0927-7757
DOI: 10.1016/j.colsurfa.2024.134188 , , , , , , , :
2023
Quaternary and pentanar mesoporous bioactive glass nanoparticles as novel nanocarriers for gallic acid: Characterisation, drug release and antibacterial activity
In: Ceramics International (2023)
ISSN: 0272-8842
DOI: 10.1016/j.ceramint.2023.06.250 , , , , :
A 3D-Printed Wound-Healing Material Composed of Alginate Dialdehyde-Gelatin Incorporating Astaxanthin and Borate Bioactive Glass Microparticles
In: ACS Applied Materials and Interfaces (2023)
ISSN: 1944-8244
DOI: 10.1021/acsami.2c23252 , , , , , , :
Flexural strength of biopolymer coated bioactive glass (45S5) sintered struts for bone tissue engineering applications
In: Materials Letters 337 (2023), Art.Nr.: 133957
ISSN: 0167-577X
DOI: 10.1016/j.matlet.2023.133957 , , , , :
Comparison of microstructure, sintering behavior, and biological response of sol-gel and melt-derived 13–93 bioactive glass scaffolds
In: Open Ceramics 15 (2023), Art.Nr.: 100407
ISSN: 2666-5395
DOI: 10.1016/j.oceram.2023.100407 , , , , , , :
2022
Effect of Boron-Doped Mesoporous Bioactive Glass Nanoparticles on C2C12 Cell Viability and Differentiation: Potential for Muscle Tissue Application
In: ACS Biomaterials Science and Engineering 8 (2022), S. 5273-5283
ISSN: 2373-9878
DOI: 10.1021/acsbiomaterials.2c00876 , , , :
A 3D Printed Bone Tissue Engineering Scaffold Composed of Alginate Dialdehyde-Gelatine Reinforced by Lysozyme Loaded Cerium Doped Mesoporous Silica-Calcia Nanoparticles
In: Macromolecular Bioscience (2022)
ISSN: 1616-5187
DOI: 10.1002/mabi.202200113 , , , , , , :
2021
Integration of mesoporous bioactive glass nanoparticles and curcumin into PHBV microspheres as biocompatible composite for drug delivery applications
In: Molecules 26 (2021), Art.Nr.: 3177
ISSN: 1420-3049
DOI: 10.3390/molecules26113177 , , , :
Synthesis, characterization, antibacterial properties, and in vitro studies of selenium and strontium co-substituted hydroxyapatite
In: International Journal of Molecular Sciences 22 (2021), Art.Nr.: 4246
ISSN: 1422-0067
DOI: 10.3390/ijms22084246 , , , , , , , , , :
3D printing of alginate dialdehyde-gelatin (ADA-GEL) hydrogels incorporating phytotherapeutic icariin loaded mesoporous SiO2-CaO nanoparticles for bone tissue engineering
In: Materials Science and Engineering C 131 (2021), Art.Nr.: 112470
ISSN: 0928-4931
DOI: 10.1016/j.msec.2021.112470 , , , , , , :
Combination of selective etching and impregnation toward hollow mesoporous bioactive glass nanoparticles
In: Nanomaterials 11 (2021), Art.Nr.: 1846
ISSN: 2079-4991
DOI: 10.3390/nano11071846 , , , , , :
Mapping the elemental and crystalline phase distribution in Cu2+ doped 45S5 bioactive glass upon crystallization
In: CrystEngComm (2021)
ISSN: 1466-8033
DOI: 10.1039/d1ce01160j , , , , , :
Multifunctional stratified composite coatings by electrophoretic deposition and RF co-sputtering for orthopaedic implants
In: Journal of Materials Science (2021)
ISSN: 0022-2461
DOI: 10.1007/s10853-020-05725-w , , , , , , , , :
Adipogenic, chondrogenic, osteogenic, and antimicrobial features of glass ceramic material supplemented with manganese
In: Journal of Non-Crystalline Solids 559 (2021), Art.Nr.: 120709
ISSN: 0022-3093
DOI: 10.1016/j.jnoncrysol.2021.120709 , , , , , , , , , , :
Impact of zinc-or copper-doped mesoporous bioactive glass nanoparticles on the osteogenic differentiation and matrix formation of mesenchymal stromal cells
In: Materials 14 (2021), Art.Nr.: 1864
ISSN: 1996-1944
DOI: 10.3390/ma14081864 , , , , , , , :
2020
Silicate-based nanoceramics in regenerative medicine
In: Vincenzo Guarino, Michele Iafisco, Silvia Spriano (Hrsg.): Nanostructured Biomaterials for Regenerative Medicine, Elsevier, 2020, S. 255-273 (Woodhead Publishing Series in Biomaterials)
DOI: 10.1016/B978-0-08-102594-9.00009-7 , , :
Silibinin releasing mesoporous bioactive glass nanoparticles with potential for breast cancer therapy
In: Ceramics International (2020)
ISSN: 0272-8842
DOI: 10.1016/j.ceramint.2020.08.083 , , , , , :
Crystallization study of sol–gel derived 13-93 bioactive glass powder
In: Journal of the European Ceramic Society (2020)
ISSN: 0955-2219
DOI: 10.1016/j.jeurceramsoc.2020.09.052 , , , , , , , , :
New insights into the crystallization process of sol-gel–derived 45S5 bioactive glass
In: Journal of the American Ceramic Society (2020)
ISSN: 1551-2916
DOI: 10.1111/jace.17124 , , , , , , :
Electrophoretic deposition of PEEK/bioactive glass composite coatings on stainless steel for orthopedic applications: an optimization for in vitro bioactivity and adhesion strength
In: International Journal of Advanced Manufacturing Technology 108 (2020), S. 1849-1862
ISSN: 0268-3768
DOI: 10.1007/s00170-020-05456-x , , , , :
Effect of manganese, zinc, and copper on the biological and osteogenic properties of mesoporous bioactive glass nanoparticles
In: Journal of Biomedical Materials Research Part A (2020)
ISSN: 1549-3296
DOI: 10.1002/jbm.a.37136 , , , , , , , , , , :
Osteogenic properties of manganese-doped mesoporous bioactive glass nanoparticles
In: Journal of Biomedical Materials Research Part A (2020)
ISSN: 1549-3296
DOI: 10.1002/jbm.a.36945 , , , , , :
2019
Bioactive glass based scaffolds incorporating gelatin/manganese doped mesoporous bioactive glass nanoparticle coating
In: Ceramics International (2019)
ISSN: 0272-8842
DOI: 10.1016/j.ceramint.2019.04.179 , , , , , , :
Multifunctional zinc ion doped sol – gel derived mesoporous bioactive glass nanoparticles for biomedical applications
In: Bioactive Materials 4 (2019), S. 312-321
ISSN: 2452-199X
DOI: 10.1016/j.bioactmat.2019.10.002 , , , , , , , , :
Fabrication and characterization of electrophoretically deposited chitosan-hydroxyapatite composite coatings on anodic titanium dioxide layers
In: Electrochimica Acta 307 (2019), S. 465-473
ISSN: 0013-4686
DOI: 10.1016/j.electacta.2019.03.195 , , , , , :
Favorable angiogenic properties of the borosilicate bioactive glass 0106-B1 result in enhanced: In vivo osteoid formation compared to 45S5 Bioglass
In: Biomaterials Science 7 (2019), S. 5161-5176
ISSN: 2047-4830
DOI: 10.1039/c9bm01220f , , , , , , :
Primary osteoblasts, osteoblast precursor cells or osteoblast-like cell lines: Which human cell types are (most) suitable for characterizing 45S5-bioactive glass?
In: Journal of Biomedical Materials Research Part A (2019)
ISSN: 1549-3296
DOI: 10.1002/jbm.a.36846 , , , , , , :
2018
Synthesis and characterization of manganese containing mesoporous bioactive glass nanoparticles for biomedical applications
In: Journal of Materials Science: Materials in Medicine 29 (2018)
ISSN: 0957-4530
DOI: 10.1007/s10856-018-6070-4 , , , , , , , , :
Synthesis and characterization of manganese containing mesoporous bioactive glass nanoparticles for biomedical applications
In: Journal of Materials Science: Materials in Medicine (2018)
ISSN: 0957-4530
DOI: 10.1007/s10856-018-6070-4
URL: https://link.springer.com/article/10.1007/s10856-018-6070-4 , , , , , , :
Electrophoretic Deposition of Lawsone Loaded Nanoscale Silicate Glass /Chitosan Composite on PEEK/BG Layers
In: ECS Transactions 82 (2018), S. 45-50
ISSN: 1938-5862
DOI: 10.1149/08201.0045ecst
URL: http://ecst.ecsdl.org/content/82/1/45.abstract , , , :
Electrophoretic deposition of lawsone loaded bioactive glass (BG)/chitosan composite on polyetheretherketone (PEEK)/BG layers as antibacterial and bioactive coating.
In: Journal of Biomedical Materials Research Part A 106 (2018), S. 3111-3122
ISSN: 1549-3296
DOI: 10.1002/jbm.a.36506 , , , , , , :
2017
Correlation between product purity and process parameters for the synthesis of Cu2ZnSnS4 nanoparticles using microwave irradiation
In: Journal of Nanoparticle Research 19 (2017), Art.Nr.: 238
ISSN: 1388-0764
DOI: 10.1007/s11051-017-3932-5 , , , , :
Antibacterial and Bioactive Coatings Based on Radio Frequency Co-Sputtering of Silver Nanocluster-Silica Coatings on PEEK/Bioactive Glass Layers Obtained by Electrophoretic Deposition
In: ACS Applied Materials and Interfaces 9 (2017), S. 32489-32497
ISSN: 1944-8244
DOI: 10.1021/acsami.7b08646 , , , , , , , , :